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The Lexington Weekly Press was published every Wednesday in Lexington, Kentucky, and contained local, state, and foreign news. The paper focused on Central Kentucky’s “agriculture, manufactures and fine stock”, as well as literary and scientific news, market reports, and serial stories. Local weddings, deaths, community events, and elections for Lexington and the surrounding region. The paper was sent anywhere in the United States at a cost of one dollar per year.

The True American was an anti-slavery newspaper started by Cassius Marcellus Clay in June 1845. He ran the paper in Lexington until August of 1845, when he published an article deemed so incendiary that at court injunction was issued against his printing, and his press shipped to Cincinnati. An advocate of the right to a free press, and his right of free speech, Clay continued printing the paper through 1847 in Cincinnati. The paper was distributed in Lexington. While focused on advancing the cause of emancipation, Clay also published poetry, agriculture, labor, and commercial news. There are also marriage and death notices from the surrounding area, some national.